Thursday, December 19, 2019

Is there a link between lifetime lead exposure and dementia?

News Release 19-Dec-2019
University of Toronto

To the medical community's surprise, several studies from the US, Canada, and Europe suggest a promising downward trend in the incidence and prevalence of dementia. Important risk factors for dementia, such as mid-life obesity and mid-life diabetes, have been increasing rapidly, so the decline in dementia incidence is particularly perplexing.

A new hypothesis by University of Toronto Professor Esme Fuller-Thomson, recently published in the Journal of Alzheimer's Disease, suggests that the declining dementia rates may be a result of generational differences in lifetime exposure to lead. U of T pharmacy student ZhiDi (Judy) Deng, co-authored the article.


Leaded gasoline was a ubiquitous source of air pollution between the 1920s and 1970s. As it was phased out, beginning in 1973, levels of lead in citizens' blood plummeted. Research from the 1990s indicates that Americans born before 1925 had approximately twice the lifetime lead exposure as those born between 1936 and 1945.

"The levels of lead exposure when I was a child in 1976 were 15 times what they are today," says Fuller-Thomson, who is also cross appointed with U of T's Faculty of Medicine. "Back then, 88 per cent of us had blood lead levels above 10 micrograms per deciliter. To put this numbers in perspective, during the Flint Michigan water crisis of 2014, one per cent of the children had blood lead levels above 10 micrograms per deciliter."

Lead is a known neurotoxin that crosses the blood-brain barrier. Animal studies and research on individuals occupationally exposed to lead suggest a link between lead exposure and dementia. Other studies have shown a higher incidence of dementia among older adults living closer to major roads and among those with a greater exposure to traffic related pollution.


Other plausible explanations for the improving trends in dementia incidence include higher levels of educational attainment, lower prevalence of smoking, and better control of hypertension among older adults today compared to previous generations. However, even when these factors are statistically accounted for, many studies still find incidences of dementia declining.


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