Nature or Nurture? It May Depend On Where You Live

http://www.sciencedaily.com/releases/2012/06/120612101334.htm

ScienceDaily (June 12, 2012) — In a study published June 12 in the journal Molecular Psychiatry, researchers from the Twins Early Development Study at King's College London's Institute of Psychiatry studied data from more than 6700 families relating to 45 childhood characteristics, from IQ and hyperactivity to height and weight. They found that genetic and environmental contributions to these characteristics vary geographically in the UK and have published their results online as a series of nature-nurture maps.

Our development, health and behaviour are determined by complex interactions between our genetic make-up and the environment in which we live. For example, we may carry genes that increase our risk of developing type 2 diabetes, but if we eat a healthy diet and get sufficient exercise, we may not develop the disease. Similarly, someone may carry genes that reduce his or her risk of developing lung cancer, but heavy smoking may still lead to the disease.

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"These days we're used to the idea that it's not a question of nature or nurture; everything, including our behaviour, is a little of both," explains Dr Oliver Davis, a Sir Henry Wellcome Postdoctoral Fellow at King's College London's Institute of Psychiatry. "But when we saw the maps, the first thing that struck us was how much the balance of genes and environments can vary from region to region."

"Take a trait like classroom behaviour problems. From our maps we can tell that in most of the UK around 60 per cent of the difference between people is explained by genes. However, in the South East genes aren't as important: they explain less than half of the variation. For classroom behaviour, London is an 'environmental hotspot'."

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"The nature-nurture maps help us to spot patterns in the complex data and to try to work out what's causing these patterns," says Dr Davis. "For our classroom behaviour example, we realised that one thing that varies more in London is household income. When we compare maps of income inequality to our nature-nurture map for classroom behaviour, we find income inequality may account for some of the pattern.

"Of course, this is just one example. There are any number of environments that vary geographically in the UK, from social environments like healthcare or education provision to physical environments like altitude, the weather or pollution.

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For example, researchers searching for gene variants that increase the risk of hay fever may study populations from two regions. In the first region people live among fields of wind-pollinated crops, whereas the second region is miles away from those fields. In this second region, where no one is exposed to pollen, no one develops hay fever; hence any genetic differences between people living in this region would be invisible.

By contrast, in the first region, where people live among the fields of crops, they will all be exposed to pollen and differences between the people with a genetic susceptibility to hay fever and the people without will stand out. That would make the region a genetic hotspot for hay fever.

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