Monday, April 18, 2022

Study: Black kidney transplant patients exhibit faster clearance rates of key immunosuppressive medicine tacrolimus


 News Release 18-Apr-2022
Peer-Reviewed Publication
University at Buffalo


Kidney transplant survival is shorter, on average, in Black recipients compared to white recipients receiving similar treatment. Although Black people make up only 13% of the population, they represent 35% of patients with kidney failure in the United States, according to the National Institute of Diabetes and Digestive and Kidney Diseases.

A variety of factors influence kidney transplant survival in Black recipients, including socioeconomics, genomics and attaining adequate blood concentrations of prescribed immunosuppressive medications.

Black kidney transplant recipients have a faster clearance rate of the immunosuppressive drug tacrolimus than white recipients, according to a new study led by Kathleen Tornatore, PharmD, professor of pharmacy practice in the University at Buffalo School of Pharmacy and Pharmaceutical Sciences. The study, published earlier this year in Pharmacotherapy, is one of the first to examine how both race and sex influence tacrolimus pharmacokinetics (the study of how drugs move throughout the body). 



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