Organ transplant recipients remain vulnerable to COVID-19 even after second vaccine dose

https://www.eurekalert.org/pub_releases/2021-05/jhm-otr050621.php

 

News Release 6-May-2021
Johns Hopkins Medicine researchers urge people who are immunocompromised to strictly follow COVID-19 safety measures, even after vaccination
Johns Hopkins Medicine

 

In a study published today in the Journal of the American Medical Association (JAMA), Johns Hopkins Medicine researchers show that although two doses of a vaccine against SARS-CoV-2 -- the virus that causes COVID 19 -- confers some protection for people who have received solid organ transplants, it's still not enough to enable them to dispense with masks, physical distancing and other safety measures.

This is a follow-up study to an earlier one published in March in JAMA, in which the researchers reported that only 17% of the participating transplant recipients produced sufficient antibodies after just one dose of a two-dose COVID-19 vaccine regimen.

"While there was an increase in those with detectable antibodies -- 54% overall -- after the second shot, the number of transplant recipients in our second study whose antibody levels reached high enough levels to ward off a SARS-CoV-2 infection was still well below what's typically seen in people with healthy immune systems," says study lead author Brian Boyarsky, M.D., a surgery resident at the Johns Hopkins University School of Medicine.

"Based on our findings, we recommend that transplant recipients and other immunocompromised patients continue to practice strict COVID-19 safety precautions, even after vaccination," Boyarsky says.

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