Eradicating Dangerous Bacteria May Cause Permanent Harm

http://www.sciencedaily.com/releases/2011/08/110824131547.htm

ScienceDaily (Aug. 28, 2011) — In the zeal to eliminate dangerous bacteria, it is possible that we are also permanently killing off beneficial bacteria as well, posits Martin Blaser, MD, Frederick H. King Professor of Medicine, professor of Microbiology and chair of the Department of Medicine at NYU Langone Medical Center.

By the time a child in the US or other developed countries reaches the age of 18, s/he has already had on average 10-20 doses of antibiotics. These are in addition to the antibiotics that may be given to women while they are pregnant, and which may affect the normal bacteria that mothers transmit to their children.

The discovery and use of antibiotics has helped to increase life expectancy. However they are non-discriminatory and destroy even friendly bacteria, not just harmful ones. Scientists have found that some of the beneficial bacteria may never recover and that these extinctions may lead to increased susceptibility to infections and disease. As a result, antibiotic use could be contributing to the increases in obesity, allergies and asthma, inflammatory bowel disease, and type 1 diabetes that are occurring throughout the developed world.

Dr. Blaser urges physicians to curtail the use of these drugs immediately, and recommends that narrow spectrum, and more targeted drugs be used in their place. To be successful, this shift will require a significant effort to develop new antibacterials and new diagnostic tests that will permit the use of targeted agents.


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