Wednesday, December 30, 2009

Solution to killer superbug found in Norway

http://news.yahoo.com/s/ap/20091230/ap_on_he_me/when_drugs_stop_working_norway_s_answer;_ylt=AsGaIQRzrxlUY.QEO4a.vRas0NUE;_ylu=X3oDMTRiY29kcTI2BGFzc2V0A2FwLzIwMDkxMjMwL3doZW5fZHJ1Z3Nfc3RvcF93b3JraW5nX25vcndheV9zX2Fuc3dlcgRjY29kZQNtb3N0cG9wdWxhcgRjcG9zAzgEcG9zAzUEcHQDaG9tZV9jb2tlBHNlYwN5bl9oZWFkbGluZV9saXN0BHNsawNzb2x1dGlvbnRva2k-

By MARTHA MENDOZA and MARGIE MASON, Associated Press Writers Martha Mendoza And Margie Mason, Associated Press Writers – 21 mins ago

OSLO, Norway – Aker University Hospital is a dingy place to heal. The floors are streaked and scratched. A light layer of dust coats the blood pressure monitors. A faint stench of urine and bleach wafts from a pile of soiled bedsheets dropped in a corner.

Look closer, however, at a microscopic level, and this place is pristine. There is no sign of a dangerous and contagious staph infection that killed tens of thousands of patients in the most sophisticated hospitals of Europe, North America and Asia this year, soaring virtually unchecked.

The reason: Norwegians stopped taking so many drugs.

Twenty-five years ago, Norwegians were also losing their lives to this bacteria. But Norway's public health system fought back with an aggressive program that made it the most infection-free country in the world. A key part of that program was cutting back severely on the use of antibiotics.

Now a spate of new studies from around the world prove that Norway's model can be replicated with extraordinary success, and public health experts are saying these deaths — 19,000 in the U.S. each year alone, more than from AIDS — are unnecessary.

"It's a very sad situation that in some places so many are dying from this, because we have shown here in Norway that Methicillin-resistant Staphylococcus aureus (MRSA) can be controlled, and with not too much effort," said Jan Hendrik-Binder, Oslo's MRSA medical adviser. "But you have to take it seriously, you have to give it attention, and you must not give up."

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Convenience stores in downtown Oslo are stocked with an amazing and colorful array — 42 different brands at one downtown 7-Eleven — of soothing, but non-medicated, lozenges, sprays and tablets. All workers are paid on days they, or their children, stay home sick. And drug makers aren't allowed to advertise, reducing patient demands for prescription drugs.

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Norway responded swiftly to initial MRSA outbreaks in the 1980s by cutting antibiotic use. Thus while they got ahead of the infection, the rest of the world fell behind.

In Norway, MRSA has accounted for less than 1 percent of staph infections for years. That compares to 80 percent in Japan, the world leader in MRSA; 44 percent in Israel; and 38 percent in Greece.

In the U.S., cases have soared and MRSA cost $6 billion last year. Rates have gone up from 2 percent in 1974 to 63 percent in 2004. And in the United Kingdom, they rose from about 2 percent in the early 1990s to about 45 percent, although an aggressive control program is now starting to work.

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But can Norway's program really work elsewhere?

The answer lies in the busy laboratory of an aging little public hospital about 100 miles outside of London. It's here that microbiologist Dr. Lynne Liebowitz got tired of seeing the stunningly low Nordic MRSA rates while facing her own burgeoning cases.

So she turned Queen Elizabeth Hospital in Kings Lynn into a petri dish, asking doctors to almost completely stop using two antibiotics known for provoking MRSA infections.

One month later, the results were in: MRSA rates were tumbling. And they've continued to plummet. Five years ago, the hospital had 47 MRSA bloodstream infections. This year they've had one.

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Beth Reimer of Batavia, Ill., became an advocate for MRSA precautions after her 5-week-old daughter Madeline caught a cold that took a fatal turn. One day her beautiful baby had the sniffles. The next?

"She wasn't breathing. She was limp," the mother recalled. "Something was terribly wrong."

MRSA had invaded her little lungs. The antibiotics were useless. Maddie struggled to breathe, swallow, survive, for two weeks.

"For me to sit and watch Madeline pass away from such an aggressive form of something, to watch her fight for her little life — it was too much," Reimer said.

Since Madeline's death, Reimer has become outspoken about the need for better precautions, pushing for methods successfully used in Norway. She's stunned, she said, that anyone disputes the need for change.

"Why are they fighting for this not to take place?" she said.

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"Why are they fighting for this not to take place?" For some, it's just because they are conservative by nature, and are uncomfortable with change. But for some, it's because they don't want to lose money.

What I don't like is that in the U.S., it seems to be more of a problem than in many other countries, of powerful people who are willing and able to block changes needed to save many lives, whether it be in medicine, the environment, product safety.

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