https://www.eurekalert.org/pub_releases/2021-03/tmsh-sso030821.php
News Release 10-Mar-2021
The Mount Sinai Hospital / Mount Sinai School of Medicine
A single shot of one of the currently authorized COVID-19 vaccines may be sufficient to provide immunity to individuals who have previously been infected by the virus, thus eliminating the need for a second dose and helping to stretch severely limited vaccine supplies, a study from Mount Sinai has found. Such a change in public health policy could also spare these individuals the unnecessary side effects of a second dose of vaccine, which researchers found to be significantly greater in individuals with pre-existing immunity to SARS-CoV-2, the virus that causes COVID-19. A letter to the editor was published today in the New England Journal of Medicine detailing the study.
"We showed that the antibody response to the first vaccine dose in people with pre-existing immunity is equal to or even exceeds the response in uninfected people after the second dose," says co-author Viviana Simon, MD, PhD, Professor in the Departments of Microbiology and Medicine (Infectious Diseases) in the Icahn School of Medicine at Mount Sinai. "For that reason, we believe that a single dose of vaccine is sufficient for people who have already been infected by SARS-CoV-2 to reach immunity."
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