Mysterious disease may be tied to climate change

http://www.eurekalert.org/pub_releases/2015-10/uoca-mdm100815.php

Public Release: 8-Oct-2015
Mysterious disease may be tied to climate change, says CU Anschutz researcher
The kidney ailment has killed 20,000 since 2002
University of Colorado Anschutz Medical Campus

A mysterious kidney disease that has killed over 20,000 people in Central America, most of them sugar cane workers, may be caused by chronic, severe dehydration linked to global climate change, according to a new study by Richard J. Johnson, MD, of the University of Colorado Anschutz Medical Campus.

"This could be the first epidemic directly caused by global warming," said Johnson, professor of medicine at the University of Colorado School of Medicine and a world-renowned expert on the underlying causes of obesity, kidney disease, diabetes and hypertension. "Some districts of Nicaragua have been called the `land of widows' due to the high mortality rates occurring among the male workers from chronic kidney disease."

The epidemic was first described in 2002 and has been dubbed Mesoamerican Nephropathy. It's most prevalent among manual laborers on sugar cane plantations in the hotter, lower altitudes of Central America's Pacific coast. The disease has also been reported among farmworkers, miners, fishermen and construction and transportation workers in the region.

Theories abound about what may be causing it, including exposure to heavy metals, pesticides and other toxic chemicals. But Johnson believes the actual culprit is chronic recurrent dehydration.

His research team studied sugar cane workers in Nicaragua and El Salvador. They found that the laborers routinely worked in conditions exceeding the recommended heat standards of the U.S. Occupational Safety and Health Administration (OSHA). And even though some of them drank up to one to two liters per hour, the researchers found they still suffered serious dehydration on a daily basis.

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The study suggests that this epidemic may be gaining momentum now because global warming is increasing the risk of dehydration.

"Temperatures have been progressively increasing in El Salvador over the last century, with an average increase of 0.5 degrees Celsius since 1980," the study said. "While the overall increase in temperature may appear small, it has been shown that the small average temperature change associated with global warming are responsible for 75 percent of the moderately daily severe temperature extremes over land. "

At the same time, sugarcane cutters are working harder than ever as the worldwide demand for the product has risen.

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Johnson said that this kind of CKD is now being observed in Sri Lanka, India, Thailand, and Egypt.

He recommends improving work conditions and hydration practices among those most at risk for developing the disease.

"Adequate hydration with water and or electrolyte-containing water has been reported to prevent increases in serum uric acid that occurs with heat and exercise," he said. "We also suggest more research into the role excess uric acid plays in chronic kidney disease."

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