Schizophrenia and bipolar disorder may share genetic roots with creativity

http://www.eurekalert.org/pub_releases/2015-06/kcl-sab060815.php

Public Release: 8-Jun-2015
King's College London

Genes linked to creativity could increase the risk of developing schizophrenia and bipolar disorder, according to new research carried out by researchers at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London.

Previous studies have identified a link between creativity and psychiatric disorders such as bipolar disorder, but it has remained unclear whether this association is due to common genes. Published today in Nature Neuroscience, this new study lends support to the direct influence on creativity of genes found in people with schizophrenia and bipolar disorder.

Although creativity is difficult to define for scientific purposes, researchers consider a creative person to be someone who takes novel approaches requiring cognitive processes that are different from prevailing modes of thought or expression. Schizophrenia and bipolar disorder are disorders of thoughts and emotions, which means that those affected show alterations in cognitive and emotional processing.

It has long been suggested that creativity and psychosis show certain similarities, with notable examples of artists such as Vincent Van Gogh who themselves suffered from psychiatric illnesses. Previous studies have shown that psychiatric disorders, particularly bipolar disorder, tend to be found in the same families where creative professions are common. However, until now it had not been possible to pinpoint whether this was simply due to shared environmental factors or socioeconomic status.

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Researchers found that genetic risk scores for both schizophrenia and bipolar disorder were significantly higher in those defined as creative individuals, with scores approximately halfway between the general population and those with the disorders themselves.

These findings lend support to the direct influence of genetic factors on creativity, as opposed to the effect of sharing an environment with individuals who have schizophrenia or bipolar disorder.

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'Our findings suggest that creative people may have a genetic predisposition towards thinking differently which, when combined with other harmful biological or environmental factors, could lead to mental illness.'