https://www.eurekalert.org/pub_releases/2021-07/esfm-bcd070121.php
News Release 2-Jul-2021
ESMO World Congress on Gastrointestinal Cancer 2021
European Society for Medical Oncology
Doctors and patients are being advised to reduce unnecessary antibiotic use following new data suggesting that these medicines may increase the risk of cancer of the large intestine (colon), especially in people under 50 years. (1) The results, presented at the ESMO World Congress on Gastrointestinal Cancer (30 June-3 July) raise fresh concerns about the impact of the estimated 65% increase in global antibiotic consumption reported between 2000 and 2015, despite not showing a direct cause and effect. (2)
"To our knowledge, this is the first study to link antibiotic use with the growing risk of early onset colon cancer - a disease which has been increasing at a rate of at least 3% per year over the last two decades. (3) Junk food, sugary drinks, obesity and alcohol are likely to have played a part in that rise, but our data stress the importance of avoiding unnecessary antibiotics, especially in children and young adults," said Ms Sarah Perrott, from the University of Aberdeen, Aberdeen, UK, presenting the data.
Using a large Scottish primary care database of up to 2 million people, the study looked at nearly 8000 people with bowel cancer (colon and rectum) matched with people without bowel cancer. It found antibiotic use was associated with an increased risk of colon cancer across all ages, but the risk was increased by almost 50% in the under-50s compared to 9% in the over-50s. In the younger age group, antibiotic use was linked to cancers in the first part of the colon (the right side). Quinolones and sulfonamides/trimethoprim, which are used to treat a wide range of infections, were associated with these right-side cancers.
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