PTSD, certain prescriptions for PTSD may raise risk for dementia

https://www.eurekalert.org/pub_releases/2017-05/ags-pcp050817.php

Public Release: 8-May-2017
PTSD, certain prescriptions for PTSD may raise risk for dementia
American Geriatrics Society

Researchers are discovering that post-traumatic stress disorder (PTSD) is a significant risk factor in developing dementia. Dementia is a memory problem that affects a person's ability to carry out usual tasks. Dementia is a leading cause of serious illness, disability, and death. It often requires care in a nursing home or other long-term care facility for people aged 65 and older.

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Research has previously shown that veterans with PTSD are more likely to have health problems linked to a higher risk for dementia. These include traumatic brain injury, diabetes, chronic obstructive pulmonary disease (COPD), psychiatric disorders, substance abuse, and other health issues.

In this study, researchers discovered that taking certain antidepressants, tranquilizers, sedatives, or antipsychotic medications significantly increased veterans' risks for developing dementia compared to the risks for veterans who didn't take such medications.

Medicines that significantly increased dementia risk included:

Selective serotonin reuptake inhibitors (SSRIs)
Novel antidepressants
Atypical antipsychotics

The increase in the risk of dementia for veterans taking the drugs was the same whether or not they were diagnosed with PTSD. (This is compared to veterans who weren't taking these drugs.)

What's more, veterans who used three classes of medications were also more likely to be diagnosed with dementia whether or not they had PTSD. These medicines include:

Novel antidepressants
Serotonin-norepinephrine reuptake inhibitors (SNRIs)
Benzodiazepines

The researchers noted that an interaction among these "psychoactive" drugs could potentially affect how PTSD impacts a person's risk for developing dementia. The researchers concluded that further research should be conducted to learn more about PTSD and psychoactive drugs, including dosage, how long to take the medications, and which people could most benefit from them.