Infant vitamin B1 deficiency leads to poor motor function and balance

https://www.eurekalert.org/pub_releases/2017-03/afot-ivb032917.php

Public Release: 29-Mar-2017
Infant vitamin B1 deficiency leads to poor motor function and balance
Lack of vitamin has long-term consequences for children's health, Tel Aviv University researchers say
American Friends of Tel Aviv University

A new Tel Aviv University study published in Maternal and Child Nutrition found that infantile Vitamin B1 (thiamine) deficiency severely affected the motor function of preschoolers who were fed faulty formula in the first year of their lives. The conclusions were based on a retrospective study of children who received Remedia, an Israeli formula brand completely lacking in Vitamin B1, in 2004.

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Infant deaths caused 13 years ago by the Remedia formula brand in Israel brought to light the potentially devastating impact of vitamin B1 deficiency. The infants were hospitalized with cardiac and neurological symptoms caused by the lack of vitamin B1, which is usually found in their formula.

"At first it was a mystery," said Prof. Fattal-Valevski. "It was like an epidemic. But after the grandmothers discussed the situation in the waiting room, it became clear that the infants, all under a year old, had consumed the same formula.

"After a food technician from the Health Department confirmed the total lack of vitamin B1 in the formula, we immediately provided the infants with supplements. Some recovered quickly, but three infants died and about 20 infants were left with severe disabilities and epilepsy."

"The body's capacity for storing Vitamin B1 is limited," said Prof. Fattal-Valevski. "Unlike vitamin B12, vitamin B1 is only stored in the body for three weeks. It needs to be frequently replenished. It is critical to be aware of how important this vitamin is for child development. Even healthy babies might be at risk for B1 deficiency. If your infant is suffering from virus after virus, you must intervene with extra vitamins. But it's a vicious cycle, because one of the first symptoms of lack of B1 in the system is an absence of appetite.

"We've proven that B1 deficiency in infancy has long-term implications on gross and fine motor function and balance skills in childhood," said Prof. Fattal-Valevski. "Our study emphasizes the importance of proper infant feeding and regulatory control of breast milk substitutes."

The researchers are now focused on the link between infant B1 deficiency and later learning disabilities.