Studies offer new evidence for possible link between blood type & COVID-19 susceptibility

https://www.eurekalert.org/pub_releases/2020-10/asoh-son100720.php

News Release 14-Oct-2020
Individuals with blood type O may have lowest risk of infection; individuals with A and AB may have increased risk of severe clinical outcomes
American Society of Hematology

Two studies published today in Blood Advances suggest people with blood type O may have a lower risk of COVID-19 infection and reduced likelihood of severe outcomes, including organ complications, if they do get sick.

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The study results suggest that people with blood types A, B, or AB may be more likely to be infected with COVID-19 than people with type O. The researchers did not find any significant difference in rate of infection between A, B, and AB types. Since blood group distributions vary among ethnic subgroups, the researchers also controlled for ethnicity and maintained that fewer people with blood type O tested positive for the virus.

"It is very important to consider the proper control group because blood type prevalence may vary considerably in different ethnic groups and different countries," said study author Torben Barington, MD, of Odense University Hospital and the University of Southern Denmark. "We have the advantage of a strong control group - Denmark is a small, ethnically homogenous country with a public health system and a central registry for lab data - so our control is population-based, giving our findings a strong foundation."

Blood groups A and AB associated with increased risk of severe clinical outcomes of COVID-19 infection People with blood groups A or AB appear to exhibit greater COVID-19 disease severity than people with blood groups O or B, according to a separate retrospective study . Researchers examined data from 95 critically ill COVID-19 patients hospitalized in Vancouver, Canada. They found that patients with blood groups A or AB were more likely to require mechanical ventilation, suggesting that they had greater rates of lung injury from COVID-19. They also found more patients with blood group A and AB required dialysis for kidney failure.

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