https://www.eurekalert.org/pub_releases/2020-10/acs-eaa102320.php
News Release 28-Oct-2020
American Chemical Society
Perfluoroalkyl substances (PFASs) have received intense scrutiny in recent years because of their persistence in the environment and potential endocrine-disrupting effects. However, their estrogenic activities are controversial, with different studies showing apparently contradictory results. Now, researchers reporting in ACS' Environmental Science & Technology have used a combination of laboratory experiments and computer modeling to reveal that PFASs can interact with the estrogen receptor in different ways to influence estrogen-controlled gene expression.
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The researchers tested the estrogenic and anti-estrogenic behaviors of 10 PFASs using human cells. They found that two of the compounds mimicked estrogen's ability to activate transcription, whereas three others inhibited expression of a reporter gene. However, when the researchers also added estrogen to the cells, all of the compounds blocked the natural hormone's activity.
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