https://www.eurekalert.org/pub_releases/2020-10/bcom-gpg101520.php
News Release 15-Oct-2020
Baylor College of Medicine
Premature aging in people with HIV is now recognized as a new, significant public health challenge. Accumulating evidence shows that people with HIV who are between 45 to 60 years old develop characteristics typically observed in people without HIV that are more than 70 years of age. For instance, declining gait speed, physical function and cognition, mitochondrial aging, elevated inflammation, immune dysfunction, frailty and other health conditions are significantly higher in people with HIV when compared to age- and sex-matched uninfected people.
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"The work presented here, published in the journal Biomedicines,
builds a bridge between laboratory bench and bedside by showing
proof-of-concept that supplementing people with HIV specifically with a
combination of glycine and N-acetylcysteine, which we call GlyNAC, as
precursors of glutathione, a major antioxidant produced by the body,
improves multiple deficits associated with premature aging," said
Sekhar.
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