What your father ate before you were born could influence your health

http://www.eurekalert.org/pub_releases/2015-12/uoct-wyf120315.php

Public Release: 4-Dec-2015
What your father ate before you were born could influence your health
University of Copenhagen The Faculty of Health and Medical Sciences

There is increasing evidence that parents' lifestyle and the environment they inhabit even long before they have children may influence the health of their offspring. A current study, led by researchers from the Novo Nordisk Foundation Center for Basic Metabolic Research, sheds light on how.

Researchers in Associate Professor Romain Barrès' laboratory compared sperm cells from 13 lean men and 10 obese men and discovered that the sperm cells in lean and obese men, respectively, possess different epigenetic marks that could alter the next generation's appetite, as reported in the medical journal Cell Metabolism.

A second major discovery was made as researchers followed six men before and one year after gastric-bypass surgery (an effective intervention to lose weight) to find out how the surgery affected the epigenetic information contained in their sperm cells. The researchers observed an average of 4,000 structural changes to sperm cell DNA from the time before the surgery, directly after, and one year later.

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"Epidemiological observations revealed that acute nutritional stress, e.g. famine, in one generation can increase the risk of developing diabetes in the following generations," Romain Barrès states. He also referenced a study that showed that the availability of food in a small Swedish village during a time of famine correlated with the risk of their grandchildren developing cardiometabolic diseases.

The grandchildren's health was likely influenced by their ancestors' gametes (sperm or egg), which carried specific epigenetic marks - e.g. chemical additions to the protein that encloses the DNA, methyl groups that change the structure of the DNA once it is attached, or molecules also known as small RNAs. Epigenetic marks can control the expression of genes, which has also been shown to affect the health of offspring in insects and rodents.

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"The study raises awareness about the importance of lifestyle factors, particularly our diet, prior to conception. The way we eat and our level of physical activity before we conceive may be important to our future children's health and development," says Soetkin Versteyhe, co-first author of the paper.

It is still early days in this field of research, but the study disrupts the current assumption that the only thing our gametes carry is genetic information, and there is nothing we can do about it. Traits that we once thought were inevitable could prove modifiable, and what we do in life may have implications not only for our own health but also the health of our children and even our grandchildren.

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