Increased odds for type 2 diabetes after prenatal exposure to Ukraine famine of 1932-33

http://ekaweb02.eurekalert.org/pub_releases/2015-09/cums-iof090315.php

Public Release: 3-Sep-2015
Increased odds for type 2 diabetes after prenatal exposure to Ukraine famine of 1932-33
Columbia University's Mailman School of Public Health

Men and women exposed in early gestation to the man-made Ukrainian Famine of 1932-33 in regions with extreme food shortages were 1.5 times more likely to be diagnosed with Type 2 diabetes in adulthood. In regions with severe famine there was a 1.3 fold rise in the odds of Type 2 diabetes, and there was no diabetes increase among individuals born in regions with no famine.

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Scientists have long known that poor living conditions around the time of birth may have long-lasting effects on health. For Type 2 diabetes, they suspected that nutrition in pregnancy was a possible explanation but studies with reliable measures of the severity and timing of under-nutrition in pregnancy in large representative populations were not yet available.

The new Lancet study included all 43,150 cases of Type 2 diabetes diagnosed at age 40 or over in the Ukraine national diabetes register between 2000-2008. The researchers matched these records with all 1.4 million individuals in the 2001 census who were born in the selected regions between1930-1938 and still alive in the year 2000.

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"The most important finding of our study is the dose-response relation between the severity of famine exposure in early gestation and the likelihood of later diabetes," said L.H. Lumey, MD, Mailman School of Public Health associate professor of Epidemiology and the study's first author.

Data for the years 1932-1934 show that the odds for diabetes were highest and the birth counts lowest in early 1934, nine months after famine mortality peaked between May to July 1933. Using month of birth, the researchers identified early gestation as a timeframe that appears to be particularly sensitive to long-term effects of prenatal famine. They were able to quantify the impact of prenatal famine on Type 2 diabetes in men and women, accounting for region of birth, seasonal effects, and their possible interactions. Results were the same for both sexes.

According to the researchers, the relation between season of birth and Type 2 diabetes was likely related to seasonal differences in food availability. The authors point out that deficiencies of a low-calorie diet most likely worsen during the winter and spring when food stocks from the previous harvest are depleted. "We show that the strong season of birth effects on late life diabetes among individuals born in the years 1930-1938 in all Ukraine regions were substantially larger for births in the first half year of 1934 in famine regions, especially after famine in early gestation," noted Lumey.

"Epigenetic changes in DNA regulation in early nutrition could provide a causal link with long-term health outcomes but need further investigation ' said Lumey. "Our findings to date are very exciting however, and further expand previous insights on the importance of the early gestation period gained from famine studies in other settings. "

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