Mice exposed to environmental chemicals may show decreased physical activity in offspring

http://www.eurekalert.org/pub_releases/2015-09/uom-met092115.php

Public Release: 21-Sep-2015
Mice exposed to environmental chemicals may show decreased physical activity in offspring
University of Missouri-Columbia

Endocrine disruptors are contaminants that interfere with endocrine or hormone systems and can cause tumors, birth defects and developmental disorders in mammals. Often, these contaminants are used in a variety of consumer products, such as water bottles, dental composites and resins used to line metal food and beverage containers. Now, a University of Missouri study suggests that female mice exposed to these environmental chemicals may cause decreases in their daughter's metabolism and the amount of exercise and voluntary physical activity they engage in later in life. These disruptors when introduced in developmental stages, are essentially creating "couch potatoes" among female mice and could predict future metabolic complications, researchers say.

"We found that if we exposed mice to one of two common endocrine disruptors- bisphenol A (BPA) or ethinyl estradiol (EE), which is the estrogen present in birth control pills, during development, it caused later disruptions in voluntary physical activity once the mice became adults," said Cheryl Rosenfeld, associate professor of biomedical sciences in the College of Veterinary Medicine and a researcher in the Bond Life Sciences Center at MU. "Mice exposed to endocrine disruptors move around less, are more likely to sleep and engage in less voluntary physical activity."

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"Female mice exposed to BPA and EE were less active than the control mice," Rosenfeld said. "They moved around less at night--when these mice are typically most active--and moved more slowly, drank less water, and spent more time sleeping. In addition, BPA-exposed females burned more carbohydrates relative to fats, as compared to control mice. This is similar to the difference between obese and slender humans, and many researchers believe that burning more carbohydrates relative to fats can lead to fats gradually accumulating in the body."

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"Our findings are significant because decreased voluntary physical activity, or lack of exercise, can predispose animals or humans to cardiovascular diseases, metabolic disorders and even cancer," Rosenfeld said.