How Exercise May Protect Against Depression

See the article for details on the science.

http://well.blogs.nytimes.com/2014/10/01/how-exercise-may-protect-against-depression/?partner=MYWAY&ei=5065

By Gretchen Reynolds
October 1, 2014

Exercise may help to safeguard the mind against depression through previously unknown effects on working muscles, according to a new study involving mice. The findings may have broad implications for anyone whose stress levels threaten to become emotionally overwhelming.

Mental health experts have long been aware that even mild, repeated stress can contribute to the development of depression and other mood disorders in animals and people.

Scientists have also known that exercise seems to cushion against depression. Working out somehow makes people and animals emotionally resilient, studies have shown.

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And in the new experiment, after five weeks of frequent but intermittent, low-level stress, such as being restrained or lightly shocked, mice displayed exactly those behaviors. They became depressed.

The scientists could then have tested whether exercise blunts the risk of developing depression after stress by having mice run first. But, frankly, from earlier research, they knew it would. They wanted to parse how.

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The upshot of these results, in the simplest terms, is that “you reduce the risk of getting depression when you exercise,” said Maria Lindskog, a researcher in the department of neuroscience at the Karolinska Institute and a study co-author.

Whether the same biochemical processes likewise combat depression that already exists is less certain, said Jorge Ruas, a principal investigator at the Karolinska Institute and the study’s senior author. But he is hopeful. “We think that this mechanism would be efficient if activated after depression has begun,” he said. He and his colleagues hoped to test that possibility in mice soon.

In the meantime, if work and other pressures mount, it may be a good idea to go for a jog. It may just keep your kynurenine in check.

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