Lower asthma risk is associated with microbes in infants' homes

http://www.eurekalert.org/pub_releases/2014-06/uoc--lar060614.php

PUBLIC RELEASE DATE: 6-Jun-2014
Contact: Jeffrey Norris
University of California - San Francisco
Lower asthma risk is associated with microbes in infants' homes

UCSF researchers probe link between bacteria and allergies

Infants exposed to a diverse range of bacterial species in house dust during the first year of life appear to be less likely to develop asthma in early childhood, according to a new study published online on June 6, 2014, in the Journal of Allergy and Clinical Immunology.

Children who were neither allergic nor prone to wheezing as three-year-olds were the most likely to have been exposed to high levels of bacteria, and paradoxically, to high levels of common allergens.

In fact, some of the protective bacteria are abundant in cockroaches and mice, the source of these common allergens, according to UC San Francisco researcher Susan Lynch, PhD, a lead author for the multi-institutional study.

Lynch also found that exposure during the first year of life to household dust containing higher levels of two specific groups of bacteria that are abundant in the human gut -- Bacteriodes and Firmicutes -- was associated with less asthma risk in the analysis of data from 104 inner-city babies in four cities.

Lynch, an associate professor of medicine with the Division of Gastroenterology at UCSF, said there is no obvious mechanism explaining the association, but the evidence supports earlier research that strongly pointed to the influence of microbial species in shaping immune responses.

-----

Through the first three years of life, cumulative exposure to allergy-provoking substances from cats, mice, cockroaches and dust mites – but not from dogs -- was associated with more wheezing and allergic reaction in the new study. This was an expected result, based on earlier research. But this association was reversed when the researchers analyzed exposures for just the first year of life, when greater exposure to certain allergens, those from cockroaches and mice, was associated with less risk of wheezing and allergy at three years.

These results indicate that immune responses might be shaped by exposures during the first year of life differently than they are by later exposures. "These findings suggest that concomitant exposure to high levels of certain allergens and bacteria in early life may be beneficial," the researchers wrote in the journal paper.

If the study results are borne out in follow-up research in other populations, it might warrant testing of new strategies, Lynch said, including, "microbial supplementation to inoculate children in early life with appropriate microbes to help protect them against wheezing and allergy."

Lynch's own work and research by several others in the field has led her to become convinced that "the composition and function of the gut microbiome strongly influence immune reactions and present a novel avenue for development of therapeutics for both allergic asthma and a range of other diseases."

According to Boushey, "Strict avoidance of allergens to lower asthma risk has been unsuccessful. Maybe permitting allergen exposures, with increased exposure to the sources of certain microbes, might be more successful in reducing asthma risk."

Boushey noted that the research team's new research associating increased bacterial diversity and abundance with lower risk appears to support the "hygiene hypothesis," which suggests that the increase in the prevalence of allergies and asthma in modern, westernized countries might be an unintended consequence of children being exposed to fewer bacteria in cleaner indoor environments.

-----