BPA stimulates growth of breast cancer cells, diminishes effect of treatment

http://www.eurekalert.org/pub_releases/2014-06/dumc-bsg061914.php

PUBLIC RELEASE DATE: 23-Jun-2014
Contact: Sarah Avery
Duke University Medical Center
BPA stimulates growth of breast cancer cells, diminishes effect of treatment

DURHAM, N.C. – Bisphenol A (BPA), a chemical commonly used in plastics, appears to increase the proliferation of breast cancer cells, according to Duke Medicine researchers presenting at an annual meeting of endocrine scientists.

The researchers found that the chemical, at levels typically found in human blood, could also affect growth of an aggressive hormone-independent subtype of breast cancer cells called inflammatory breast cancer and diminish the effectiveness of treatments for the disease.

"We set out to determine whether routine exposures to common chemicals such as those in plastics, pesticides and insecticides could influence the effectiveness of breast cancer treatments," said corresponding author Gayathri Devi, Ph.D., associate professor of surgery at Duke. "BPA was one of the top chemicals to show growth stimulatory effects in breast cancer cells."

Devi and colleagues reported their findings in a featured abstract at the annual joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago, June 23, 2014.

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