Researchers reveal new cause of epilepsy

http://www.eurekalert.org/pub_releases/2014-04/sdmc-rrn043014.php

PUBLIC RELEASE DATE: 30-Apr-2014

Contact: Ron Najman
SUNY Downstate Medical Center
Researchers reveal new cause of epilepsy
Study shows the first evidence that hyaluronic acid plays a role in epileptic seizures, providing a potential new approach for treatments

A team of researchers from SUNY Downstate Medical Center (SUNY Downstate) and Sanford-Burnham Medical Research Institute (Sanford-Burnham) has found that deficiencies in hyaluronan, also known as hyaluronic acid or HA, can lead to spontaneous epileptic seizures. HA is a polysaccharide molecule widely distributed throughout connective, epithelial, and neural tissues, including the brain's extracellular space (ECS). Their findings, published on April 30 in The Journal of Neuroscience, equip scientists with key information that may lead to new therapeutic approaches to epilepsy.

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"Hyaluronan is widely known as a key structural component of cartilage and important for maintaining healthy cartilage. Curiously, it has been recognized that the adult brain also contains a lot of hyaluronan, but little is known about what hyaluronan does in the brain," said Yu Yamaguchi, MD, PhD, professor in the Human Genetics Program at Sanford-Burnham.

"This is the first study that demonstrates the important role of this unique molecule for normal functioning of the brain, and that its deficiency may be a cause of epileptic disorders. A better understanding of how hyaluronan regulates brain function could lead to new treatment approaches for epilepsy," Yamaguchi added.

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