Weight loss reduces the risk of growths linked to colorectal cancer

 

https://www.eurekalert.org/news-releases/941365

 

 News Release 1-Feb-2022
Peer-Reviewed Publication
Oxford University Press USA

 

A new paper in JNCI Cancer Spectrum, published by Oxford University Press, indicates that overweight and obese people who lose weight may reduce their chances of later developing colorectal adenoma – a type of benign growth or polyp in the colon or rectum that could lead to colorectal cancer. Colorectal cancer is the third most common type of cancer and the third leading cause of death from cancer among men and women in the United States.

Over the past 30 years, obesity has increased in the United States and worldwide, leading to increased development of many chronic diseases. Obesity is a known risk factor for colorectal adenoma and colorectal cancer.

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The investigators found that, compared to stable weight, weight loss in adulthood (defined as loss greater than or equal to 1.1 pounds per 5 years) was associated with a 46% reduced risk for colorectal adenoma. This was particularly true among adults who were initially overweight or obese. The investigators also reported that weight gain in adulthood was associated with an increased chance of adenoma, particularly for weight gain greater than 6.6 pounds over 5 years. Findings for weight loss and weight gain appeared stronger among men than women. The researchers believe that the findings suggest the importance of healthy weight maintenance throughout adulthood in preventing colorectal adenoma. Additionally, adults who are overweight or obese may be able to reduce their risk for developing colorectal adenoma by losing weight.

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