https://www.eurekalert.org/news-releases/941956
News Release 7-Feb-2022
Peer-Reviewed Publication
Canadian Medical Association Journal
A new study in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.211215 shows a small increased risk of congenital abnormalities in infants exposed to opioid medications in the first trimester of pregnancy.
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Among the infants included in the study, 2% (11 903) were exposed in utero to opioid analgesics, such as codeine, oxycodone, hydromorphone, tramadol, and morphine. The study found an increased risk, albeit low, of major anomalies with exposure to tramadol and morphine, and minor anomalies with exposure to codeine, hydromorphone and oxycodone. Specific congenital anomalies observed included gastrointestinal and genital anomalies, neoplasms and tumours, and ankyloglossia.
This large study adds to earlier evidence from studies conducted in Sweden and Norway and from a recent study of pregnant US Medicaid beneficiaries that suggested a small increased risk of congenital anomalies, an important finding for a pregnant person who may be prescribed opioids for pain relief.
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tags: drug use, drug abuse,
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