Vaccines less effective at protecting against severe COVID-19 in immunocompromised adults

 

https://www.eurekalert.org/news-releases/933567

 

 News Release 2-Nov-2021
Susceptible people should receive a 3-dose vaccine series and a booster
Reports and Proceedings
Regenstrief Institute

 

New real-world evidence gathered by the U.S. Centers for Disease Control and Prevention (CDC) shows that COVID-19 vaccines are less effective at protecting against COVID-19-associated hospitalizations in people who are immunocompromised.

In general, immunocompromised individuals are at an increased risk for severe COVID-19 outcomes.

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“These findings indicate that while two-doses of mRNA COVID-19 vaccines are beneficial in immunocompromised individuals, they are significantly less protected from severe disease than people with normal immune systems,” said study lead author Peter Embí, M.D., M.S., Regenstrief Institute president and chief executive officer and associate dean for informatics and health services research at the Indiana University School of Medicine. “Since they are less protected after a two-dose series, those who are immunocompromised should receive an additional dose and a booster, take additional precautions like masking when in public, and, if they get infected, they should seek treatment with proven therapies that can protect against progression to severe disease and the need for hospitalization.” 

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