Link between gum disease and cognitive decline in Alzheimer's

http://www.eurekalert.org/pub_releases/2016-03/kcl-lbg030916.php

Public Release: 10-Mar-2016
Link between gum disease and cognitive decline in Alzheimer's
King's College London

A new study jointly led by King's College London and the University of Southampton has found a link between gum disease and greater rates of cognitive decline in people with early stages of Alzheimer's Disease.

Periodontitis or gum disease is common in older people and may become more common in Alzheimer's disease because of a reduced ability to take care of oral hygiene as the disease progresses. Higher levels of antibodies to periodontal bacteria are associated with an increase in levels of inflammatory molecules elsewhere in the body, which in turn has been linked to greater rates of cognitive decline in Alzheimer's disease in previous studies.

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The presence of gum disease at baseline was associated with a six-fold increase in the rate of cognitive decline in participants over the six-month follow-up period of the study. Periodontitis at baseline was also associated with a relative increase in the pro-inflammatory state over the six-month follow-up period. The authors conclude that gum disease is associated with an increase in cognitive decline in Alzheimer's Disease, possibly via mechanisms linked to the body's inflammatory response.

Limitations of the study included the small number of participants; the authors advise that the study should be replicated ideally with a larger cohort.

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However, growing evidence from a number of studies links the body's inflammatory response to increased rates of cognitive decline, suggesting that it would be worth exploring whether the treatment of gum disease might also benefit the treatment of dementia and Alzheimer's Disease.

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