Taking vitamin D may benefit people with MS

I am unhappy that, as with other MS research I have seen, only patients with relapsing-remitting MS were treated. I have a friend with chronic MS, and he rejects the possibility of trying such treatments to see if they would help because he doesn't have relapsing-remitting MS.

http://www.eurekalert.org/pub_releases/2015-12/aaon-tvd122315.php

Public Release: 30-Dec-2015
Taking vitamin D may benefit people with MS
American Academy of Neurology

Taking a high dose of vitamin D3 is safe for people with multiple sclerosis (MS) and may correct the body's hyperactive immune response, according to a study published in the Dece. 30, 2015, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Low levels of vitamin D in the blood are tied to an increased risk of developing MS. People who have MS and low levels of vitamin D are more likely to have greater disability and more disease activity.

For the study, 40 people with relapsing-remitting MS received either 10,400 IU or 800 IU of vitamin D3 supplements per day for six months. The current recommended daily allowance of vitamin D3 is 600 IU. Blood tests at the start of the study and again at three and six months measured the amount of vitamin D in the blood and the response in the immune system's T cells, which play a key role in MS.

Side effects from the vitamin supplements were minor and were not different between the people taking the high dose and the people taking the low dose. One person in each group had a relapse of disease activity.

The people taking the high dose had a reduction in the percentage of T cells related to MS activity. When the increase in vitamin D in the blood was greater than 18 nanograms per milliliter (ng/ml), every 5 ng/ml increase in vitamin D led to a 1 percent decrease in the percentage of interleukin 17 T cells in the blood. The people taking the low dose did not have any changes in their T cells.

While researchers are still determining the optimal level of vitamin D in the blood for people with MS, the people in the study taking the high dose of vitamin D reached a level that has been proposed as a target for people with MS. Vitamin D levels above 30 ng/ml are considered sufficient for the general population, but researchers noted that for people with MS, it may be that levels above 50 ng/ml are necessary to reduce disease activity. The group taking the low dose did not reach this target.

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