Study links exposure to common pesticide with ADHD in boys

http://www.eurekalert.org/pub_releases/2015-06/cchm-sle060115.php

Public Release: 1-Jun-2015
Cincinnati Children's Hospital Medical Center

A new study links a commonly used household pesticide with attention deficit hyperactivity disorder (ADHD) in children and young teens.

The study found an association between pyrethroid pesticide exposure and ADHD, particularly in terms of hyperactivity and impulsivity, rather than inattentiveness. The association was stronger in boys than in girls.

The study, led by researchers at Cincinnati Children's Hospital Medical Center, is published online in the journal Environmental Health.

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ADHD was determined by meeting criteria on the Diagnosic Interview Schedule for Children, a diagnostic instrument that assesses 34 common psychiatric diagnoses of children and adolescents, or by caregiver report of a prior diagnosis. The DISC is administered by an interviewer.

Boys with detectable urinary 3-PBA, a biomarker of exposure to pyrethroids, were three times as likely to have ADHD compared with those without detectable 3-PBA. Hyperactivity and impulsivity increased by 50 percent for every 10-fold increase in 3-PBA levels in boys. Biomarkers were not associated with increased odds of ADHD diagnosis or symptoms in girls.

"Our study assessed pyrethroid exposure using 3-PBA concentrations in a single urine sample," says Dr. Froehlich. "Given that pyrethroids are non-persistent and rapidly metabolized, measurements over time would provide a more accurate assessment of typical exposure and are recommended in future studies before we can say definitively whether our results have public health ramifications."