Coffee increases prediabetes risk in susceptible young adults

http://www.eurekalert.org/pub_releases/2014-09/esoc-cip082214.php

PUBLIC RELEASE DATE: 2-Sep-2014

Contact: ESC Press Office
European Society of Cardiology
Coffee increases prediabetes risk in susceptible young adults

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Barcelona, Spain – Tuesday 2 September 2014: Coffee increases the risk of prediabetes in young adults with hypertension who are slow caffeine metabolisers, according to results from the HARVEST study presented at ESC Congress today by Dr Lucio Mos from Italy. People who drank more than three cups of coffee per day doubled their risk of prediabetes.

Dr Mos said: "Lifestyle factors are very important for the prognosis of young people with hypertension. In a previous analysis of HARVEST (Hypertension and Ambulatory Recording VEnetia STudy) we found that coffee was a risk factor for the development of sustained hypertension and that the risk was modulated by the genetic background of the individual. Slow metabolisers of caffeine were at increased risk of hypertension."(

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Dr Mos said: "Our study shows that drinking coffee increases the risk of prediabetes in young adults with hypertension who are slow caffeine metabolisers. The risk is even greater if these individuals are overweight or obese, and if they are heavy drinkers of coffee."

He added: "Slow caffeine metabolisers are exposed for a longer time to the detrimental effects of caffeine on glucose metabolism. Thus, the effect of coffee on prediabetes depends on two factors, the amount of daily coffee intake and the individual's genetic background."

He continued: "Young-to-middle-age people with hypertension should be aware that coffee consumption may increase their risk of developing diabetes in later life. Genotyping for the CYP1A2 gene polymorphism could help them to better know their risk. Carriers of the slow *1F allele, who are slow caffeine metabolisers, should abstain from drinking caffeinated coffee."

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