Calcium in Early Life May Prevent Obesity Later

http://www.sciencedaily.com/releases/2010/05/100513123833.htm

ScienceDaily (May 13, 2010) — There's no denying that people need calcium for strong, healthy bones. But new research from North Carolina State University suggests that not getting enough calcium in the earliest days of life could have a more profound, lifelong impact on bone health and perhaps even obesity than previously thought.

During an 18-day trial involving 24 newborn pigs, the researchers documented markedly lower levels of bone density and strength in 12 piglets fed a calcium-deficient diet compared to 12 piglets that received more calcium. Not only that, but when researchers looked at certain stem cells in bone marrow, they found that many of these cells in the calcium-deficient piglets appeared to have already been programmed to become fat cells instead of bone-forming cells.



Because these programmed mesenchymal stem cells replicate to provide all the bone-forming cells for an animal's entire life, very early calcium deficiency may have predisposed the piglets to have bones that contain more fat and less mineral. That could make those pigs more prone to osteoporosis and obesity in later life, said Dr. Chad Stahl, an associate professor of animal science who led the study.

In a longer-term study that Stahl plans to begin this month, the researchers will look at whether that's the case: By conducting a longer feeding trial, the scientists will be able to see if the changes persist through sexual maturity, which occurs for pigs at around eight months of age.

The researchers are using pigs as a model for human health because pigs and humans are similar when it comes to bone growth and nutrition. Pigs are one of the few animals known to experience bone breaks related to osteoporosis, Stahl said.

One of the most surprising findings of the 18-day feeding study was that while the calcium-deficient pigs had substantially lower bone strength and density, blood tests didn't indicate any difference in levels of the hormonal form of vitamin D, which regulates the amount of calcium circulating in the blood of older children and adults. Stahl said this suggests that calcium regulation in newborns isn't dependent on vitamin D.

Stahl thinks the research is relevant to the infant food industry and suggests the significance of the nutritional status of breastfeeding mothers. It also points to a need for greater emphasis in very early life on bone health, not just during those times when children are growing most rapidly.

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