Youth depression tied to higher risk of 66 diseases and premature death

https://www.eurekalert.org/pub_releases/2020-12/ki-ydt120820.php

 

News Release 9-Dec-2020
Karolinska Institutet

 

Depressed children and teenagers have an increased risk of suffering from premature death and a wide range of illnesses later in life. That is according to a large observational study by researchers at Karolinska Institutet in Sweden. The findings highlight the need to look for other potential diseases following childhood or adolescent depression. Other psychiatric conditions, such as anxiety and substance misuse, can explain part of the association. The study is published in the journal JAMA Psychiatry.


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Depression is rarely diagnosed in young children but increases in prevalence through the teenage years. Previous studies have linked depression in adolescents to an increased risk of several adverse outcomes, including atherosclerosis, cardiovascular disease and premature death. Other psychiatric conditions, such as anxiety and substance use disorder, are also commonly linked.

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The researchers followed almost 1.5 million Swedish girls and boys, of whom more than 37,000 were diagnosed with depression at least once between the ages of 5 and 19. When the research concluded, they were between 17 and 31 years old.

The study found that children and teenagers with depression had a higher risk of being diagnosed with 66 out of 69 examined medical conditions, including sleep disorders, type 2 diabetes, viral hepatitis, and kidney and liver diseases. Compared to those without depression, they also had a significantly higher risk of injuries, especially injuries inflicted by self-harm, and an almost six-fold higher risk of premature death.

The findings also revealed sex differences. For example, women with early onset depression were more likely to suffer injuries as well as urinary, respiratory and gastrointestinal infections. Men, on the other hand, were more likely to have obesity, thyroid gland problems, coeliac disease, connective tissue disorders and eczema.

Part of the association may be explained by other co-existing psychiatric conditions, especially substance use disorder and anxiety, which have previously been linked to risk increases for certain medical outcomes. These psychiatric conditions often appear in the same patient and therefore more studies are needed to examine the specific effect of each condition, according to the researchers.

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