https://www.eurekalert.org/pub_releases/2020-09/sri-lcr090820.php
News Release 8-Sep-2020
Scripps Research Institute
Cutting calories significantly may not be an easy task for most, but it's tied to a host of health benefits ranging from longer lifespan to a much lower chance of developing cancer, heart disease, diabetes and neurodegenerative conditions such as Alzheimer's.
A new study from teams led by Scripps Research Professors Bruno Conti, PhD, and Gary Siuzdak, PhD, illuminates the critical role that body temperature plays in realizing these diet-induced health benefits. Through their findings, the scientists pave the way toward creating a medicinal compound that imitates the valuable effects of reduced body temperature.
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One consistent observation is that when mammals consume less food, their body temperature drops. It's evolution's way of helping us conserve energy until food is available again, Conti explains. It makes sense, considering that up to half of what we eat every day is turned into energy simply to maintain our core body temperature.
Conti's previous work showed that temperature reduction can increase lifespan independently of calorie restriction--and that these effects involve activation of certain cellular processes, most of which remain to be identified.
On the flip side, studies have shown that preventing body temperature from dropping can actually counteract positive effects of calorie restriction. Notably, in an experiment involving calorie-restricted mice, anti-cancer benefits were diminished when core body temperature remained the same.
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