Newly discovered mechanism can explain increased risk of dementia

https://www.eurekalert.org/pub_releases/2020-05/ki-ndm050620.php

News Release 8-May-2020
Karolinska Institutet


Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report that how the long-term use of these drugs could increase the risk of developing dementia. Their results are published in the journal Alzheimer's & Dementia.

"We've been able to show that proton pump inhibitors affect the synthesis of the neurotransmitter acetylcholine, which plays a significant part in conditions such as Alzheimer's disease," says Taher Darreh-Shori, senior researcher at the Department of Neurobiology, Care Sciences and Society, Karolinska Institutet. "Since there's no effective treatment for the disease, it's important to avoid risk factors. We therefore want to draw attention to this so that the drugs aren't used needlessly for a long time."

•••••

"Special care should be taken with the more elderly patients and those already diagnosed with dementia," he says. "The same also applies to patients with muscle weakness diseases such as ALS, as acetylcholine is an essential motor neurotransmitter. In such cases, doctors should use the drugs that have the weakest effect and prescribe them at lowest dose and for as short a time as possible."

"I would, however, like to stress that the correct use of the drugs is safe also in the elderly, as long as the drugs are used for a limited time and when they're really needed, as our nervous system is pretty flexible when it comes to tolerating short-term impact," he adds.

•••••